The Cascade Lakes Rail Line Infestation is a Highway 97 nest-clearing job along the old rail line, with 5 nests to burn. It pays Diamond Lake, and Aspen Butte Ambush Camp lies just to the southwest.
Burn each nest with a Molotov or other fire, throwing from a distance with an exit open. Burning a nest draws the Freakers around it, and daylight means fewer of them are out. Railcars and sheds along the line block your view, so check them before you throw.
Until the nests are gone, fast travel through this area stays blocked. Its Diamond Lake payout is among the best for an infestation.
The rail line Horde lives along the same tracks. Clear the nests in daylight so you don't fight both at once.
Chemult College Infestation
The Chemult College Infestation is a 6-nest job at Chemult Community College, once a NERO refugee camp on Highway 97. It pays Diamond Lake and opens after the story mission You Couldn't Stop Shaking.
South Oregon Crier Infestation
The South Oregon Crier Infestation has you kill 42 Criers, infected ravens, across Highway 97. Their nests sit in trees and on power poles over a wide area rather than one zone, and the job pays Diamond Lake.
Berley Lake Infestation
The Berley Lake Infestation is a Lost Lake nest-clearing job with 4 nests to burn. It pays Iron Mike's Camp and sits near the Berley Lake Ambush Camp and the Santiam Tunnel checkpoint. You can clear all three in one trip.
Image: Bend Studio / PlayStationCrazy Willie's Infestation
Crazy Willie's Infestation is a Belknap nest-clearing job at an old roadside bar, with 4 nests to burn. It pays Hot Springs and sits close to the Belknap Caves Ambush Camp and the Iron Butte Pass checkpoint.