Pittsburgh, Pennsylvania is a former quarantine zone now run by hunters who ambush anyone passing through. Joel and Ellie spend two chapters here, Pittsburgh and The Suburbs, and meet the brothers Henry and Sam. Expect heavy human combat and the largest pile of collectibles in the game.
FEDRA ran the city under Captain Mastros. After soldiers killed people protesting ration shortages, the Fireflies stirred a revolt that lasted 14 months and drove the military out. The winners then turned on the Fireflies too, and as food ran out they began robbing and killing travelers.
A detour off the jammed highway ends in a bus ambush that crashes your truck into a store. You fight through the streets to the Hotel Grand, out through the Financial District where a hunter Humvee patrols, then meet Henry and Sam and cross the bridge at night when only a skeleton crew guards it.
Under the city lies the sewer home that a fisherman named Ish built for about 50 people from the suburbs, complete with a school and rain catchers. It fell to the infected years before you arrive. Past it, hunters with a sniper rifle and the Humvee wait in the suburbs.
BloaterBloaters are stage four infected covered in armor-like fungus. They are slow and blind but kill you instantly if they grab you, and they throw bursting sacks of mycotoxin from range. Fire is the way to beat them.Boston
Boston, Massachusetts is the first region after the time skip and the city where Ellie grew up. You play The Quarantine Zone and The Outskirts here, and Left Behind's flashbacks with Riley take place in the same city. FEDRA holds the North End as one of the last working quarantine zones in the country.
Lincoln
Lincoln is a small Massachusetts town a few miles from Boston and the setting of Bill's Town, the fourth chapter. Joel and Ellie come here to call in a favor from Bill, a paranoid survivor who has rigged the whole town with traps, because they need a working vehicle.
Salt Lake City
Salt Lake City, Utah is the last stop on Joel and Ellie's search for the Fireflies. It is an abandoned quarantine zone where the Fireflies hold Saint Mary's Hospital, and you play the Bus Depot and The Firefly Lab chapters here in spring 2034.
Jackson
Jackson, Wyoming is the home of Tommy's community and covers both the town and the wider Jackson County, including the hydroelectric dam and the Hidden Pines Corral ranch. You visit it twice: in Tommy's Dam and in the short closing chapter, Jackson. It is the one safe, working settlement in Part I.