Spitalfields is the Whitechapel gang stronghold, Rexford Kaylock's Blighter headquarters in a former silk district turned slum. Free and protect the captured Clinkers to fully sync; afterwards it becomes a Rook stronghold.
Spitalfields was home to wealthy merchants until the silk trade declined and the area sank into slums. The Clinkers held here were the last gang still standing against the Blighters, so freeing them gives the Fryes the core of their own gang.
Spitalfields is the borough's only stronghold. Whitechapel also has one bounty (Homer Dalton), one Templar hunt (Harold Drake) and the Radclyffe Mill factory, and finishing the set leads to the gang war against Kaylock.
The single optional objective is to cut the Clinkers loose and keep them alive while the Blighters fight back. Free them early so they are not caught in the middle of a long brawl, and stay close afterwards so you can step in if they are overwhelmed. Losing them costs you full sync.
The rescued Clinkers help the twins bring down Kaylock's branch of the Blighters and become the first members of the Rooks, which is how the Fryes' gang begins.
The Mother of All Crimes
The Mother of All Crimes is the eighth Jack the Ripper memory, set on 9 November 1888: Evie examines the scene of Mary Jane Kelly's murder, then follows a message from Jack back to the earlier murder sites in Spitalfields and Mitre Square, searching for clues without killing anyone.
Battersea Bellows
Battersea Bellows is a Lambeth gang stronghold that Cletus Strain built on a stretch of industrial land once full of housing. Kill the leader undetected and free the captured Rooks for full sync, then claim it for the Rooks.
Black Swan Yard
Black Swan Yard is a riverside gang stronghold in the City of London, an abandoned site Bloody Nora's Blighters took over after several failed developments. Keep lookouts from raising the alarm and kill the leader undetected for full sync.
Blue Anchor Alley
Blue Anchor Alley is a Westminster gang stronghold under heavyweight champion Lilla Graves, on ground once busy with sailors and fishmongers. Burn the heist plans and kill the leader undetected for full sync.