Spitalfields is Whitechapel's only Blighter stronghold, Rexford Kaylock's headquarters in the borough. It is the first stronghold most players take, and clearing it also rescues surviving members of the Clinkers gang.
This was once the home of the silk trade and its rich merchants. As the industry and Whitechapel declined, the area sank into a slum, and Kaylock's Blighters moved in.
Following Henry Green's lead, the twins clear the Spitalfields stronghold memory, save the Clinkers held there and give the site to the Rooks.
Freeing Spitalfields is part of the push that ends with the Whitechapel gang war, after which the twins seize Rexford Kaylock's train and make it the Assassins' mobile hideout.
The district returns in the Jack the Ripper expansion. In The Mother of All Crimes, Evie investigates Annie Chapman's murder scene near Hanbury Street in Spitalfields, where she first has to scare off the Rooks guarding it so she can work in peace.
Mitre Square
Mitre Square is a key site early in the Jack the Ripper expansion: Jack murders two Assassin initiates posing as Elizabeth Stride and Catherine Eddowes, and Jacob comes to investigate. Later Evie shuts down a fight club near the square.
Deptford
Deptford is a port on the south bank of the Thames, downriver from central London, where Jack the Ripper keeps hostages aboard old prison hulks in 1888. Evie goes there in the memory Prisoners.
Bishopsgate station
Bishopsgate station is the Whitechapel rail terminus where Jacob and Evie first arrive in London, and later the home station of the Train Hideout once the Rooks take the borough.
Buck's Row brothel
The Buck's Row brothel is Lady Owers' house in Whitechapel and the last of the three Brothel Attacks in the Jack the Ripper expansion.